Hai Yan Selected Research

homoisocitric acid

11/2012

Enzyme redesign guided by cancer-derived IDH1 mutations.

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Hai Yan Research Topics

Disease

61	Neoplasms (Cancer) 11/2021 - 01/2004
30	Glioma (Gliomas) 10/2021 - 02/2009
13	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 08/2004
8	Carcinogenesis 11/2021 - 05/2004
7	Brain Neoplasms (Brain Tumor) 01/2020 - 09/2008
5	Colorectal Neoplasms (Colorectal Cancer) 04/2014 - 05/2004
4	Type 2 Diabetes Mellitus (MODY) 01/2020 - 04/2009
4	Oligodendroglioma 09/2011 - 02/2009
3	Hyperglycemia 01/2021 - 02/2015
3	Hypoglycemia (Reactive Hypoglycemia) 06/2019 - 04/2009
3	Leukemia 01/2015 - 10/2012
3	Medulloblastoma 01/2014 - 02/2005
3	Astrocytoma (Pilocytic Astrocytoma) 12/2009 - 02/2009
2	Chondrosarcoma 10/2021 - 08/2012
2	Hepatocellular Carcinoma (Hepatoma) 01/2020 - 01/2019
2	Diffuse Intrinsic Pontine Glioma 01/2020 - 09/2017
2	Obesity 06/2019 - 08/2002
2	Heart Failure 04/2019 - 01/2019
2	Myocardial Infarction 04/2019 - 01/2019
2	Body Weight (Weight, Body) 01/2018 - 01/2017
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2018 - 02/2015
2	Atherosclerosis 05/2016 - 02/2015
2	Hypoxia (Hypoxemia) 08/2014 - 02/2012
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2012 - 08/2012
2	Stomach Neoplasms (Stomach Cancer) 08/2004 - 05/2004
1	Sepsis (Septicemia) 01/2022
1	Cholangiocarcinoma 10/2021
1	Pain (Aches) 04/2021
1	Hypersensitivity (Allergy) 04/2021
1	Infections 04/2021
1	Poliomyelitis (Polio) 01/2021
1	Pancreatic Neoplasms (Pancreatic Cancer) 03/2020
1	Liver Neoplasms (Liver Cancer) 01/2020
1	Insulin Resistance 01/2019
1	Starvation 01/2019

Drug/Important Bio-Agent (IBA)

24	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 10/2021 - 02/2009
14	EnzymesIBA 01/2021 - 12/2009
12	Proteins (Proteins, Gene)FDA Link 12/2019 - 01/2004
11	DNA (Deoxyribonucleic Acid)IBA 11/2021 - 05/2009
9	Glucagon Receptors (Glucagon Receptor)IBA 01/2021 - 12/2009
8	Telomerase (Telomerase Reverse Transcriptase)IBA 11/2021 - 04/2013
8	Biomarkers (Surrogate Marker)IBA 03/2020 - 12/2011
8	alpha-hydroxyglutarateIBA 10/2019 - 07/2010
7	NADP (NADPH)IBA 01/2015 - 02/2009
6	Biological ProductsIBA 10/2021 - 12/2009
5	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 04/2009
5	Glucagon (Glukagon)FDA Link 01/2020 - 04/2009
5	isocitric acid (isocitrate)IBA 10/2019 - 02/2009
5	Oxidoreductases (Dehydrogenase)IBA 10/2019 - 02/2009
5	Monoclonal AntibodiesIBA 06/2019 - 12/2009
4	dipinacoline glutamateIBA 11/2021 - 09/2017
4	Phosphotransferases (Kinase)IBA 01/2020 - 05/2004
4	Insulin (Novolin)FDA Link 01/2019 - 12/2009
3	MethyltransferasesIBA 01/2022 - 10/2012
3	Histones (Histone)IBA 01/2021 - 01/2011
3	Blood Glucose (Blood Sugar)IBA 06/2019 - 04/2009
3	Tyrosine (L-Tyrosine)FDA Link 09/2014 - 05/2004
2	RNA (Ribonucleic Acid)IBA 12/2019 - 01/2010
2	Cell-Free Nucleic AcidsIBA 12/2019 - 01/2019
2	MicroRNAs (MicroRNA)IBA 12/2019 - 01/2011
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019 - 09/2014
2	A-factor (Streptomyces)IBA 01/2019 - 01/2011
2	5'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)IBA 01/2019 - 01/2019
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2018 - 08/2002
2	Amino Acids FDA Link 04/2017 - 02/2009
2	Membrane Proteins (Integral Membrane Proteins)IBA 02/2015 - 09/2014
2	Transcription Factors (Transcription Factor)IBA 01/2014 - 02/2012
2	ElementsIBA 01/2014 - 09/2011
2	ChromatinIBA 01/2014 - 07/2012
2	Lysine (L-Lysine)FDA Link 11/2013 - 10/2012
2	Protein Tyrosine PhosphatasesIBA 12/2008 - 05/2004
1	LipopolysaccharidesIBA 01/2022
1	RG7388IBA 11/2021
1	Analgesics (Analgesic Drugs)IBA 04/2021
1	Fentanyl (Sublimaze)FDA LinkGeneric 04/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	Heavy MetalsIBA 01/2021
1	Temozolomide (Temodar)FDA LinkGeneric 11/2020
1	Blood Proteins (Serum Proteins)IBA 03/2020
1	SiliconIBA 03/2020
1	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	adavosertibIBA 01/2020
1	olaparibIBA 01/2020
1	GoldIBA 07/2019
1	Streptozocin (Streptozotocin)FDA Link 06/2019
1	purineIBA 01/2019
1	Circulating Tumor DNAIBA 01/2019
1	SugarsIBA 01/2019
1	SaltsIBA 01/2019
1	TeaIBA 01/2019
1	Surface Antigens (Surface Antigen)IBA 01/2019
1	Hepatitis B Surface Antigens (HBsAg)FDA Link 01/2019
1	Branched-Chain Amino AcidsIBA 01/2019
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2019

Therapy/Procedure

19	Therapeutics 10/2021 - 02/2005
3	Drug Therapy (Chemotherapy) 09/2015 - 06/2009
1	Contraindications 04/2021
1	Punctures 04/2021
1	Immunotherapy 01/2021